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DeCS
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Descriptor English:
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Multiple Endocrine Neoplasia Type 2b
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Descriptor Spanish:
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Neoplasia Endocrina Múltiple Tipo 2b
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Descriptor Portuguese:
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Neoplasia Endócrina Múltipla Tipo 2b
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Synonyms English:
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MEA 2b
MEA IIb
MEN 2b
MEN 3
MEN III
MEN IIb
MEN2b
Mucosal Neuroma Syndrome
Mucosal Neuroma Syndromes
Multiple Endocrine Neoplasia, Type 2b
Multiple Endocrine Neoplasia, Type IIb
Multiple Endocrine Neoplasms Type 2b
Neoplasia, Multiple Endocrine Type 2b
Neoplasms, Multiple Endocrine Type 2b
Neuroma Syndrome, Mucosal
Neuromata, Mucosal, With Endocrine Tumors
Syndrome, Wagenmann-Froboese
Wagenmann Froboese Syndrome
Wagenmann-Froboese Syndrome
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Tree Number:
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C04.588.322.400.510
C04.651.600.510
C04.700.630.510
C16.320.700.630.510
C19.344.400.510
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Definition English:
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Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease. |
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Indexing Annotation English:
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coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
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History Note English:
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1995; MEA III & MEN III see NEOPLASMS, MULTIPLE ENDOCRINE 1983-1994
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Allowable Qualifiers English:
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Record Number:
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32132
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Unique Identifier:
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D018814
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Occurrence in VHL:
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Similar:
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DeCS
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